山口 央輝 Yamaguchi, Hisateru

担当科目

• 臨床医学　Ⅰ
• 臨床医学　Ⅱ
• 臨床医学　Ⅲ

専門領域

• プロテオミクス
• 質量分析
• バイオインフォマティクス

研究テーマ

• マルチオミクスによる生命現象の解析

著書など

• Kawamura Y, Yamaguchi H, Nishioka T, et al. Proteomic Analysis of Serum and Cerebrospinal Fluid in Children with Encephalopathy Associated with Human Betaherpesvirus 6B. Open Forum Infectious Diseases. 2026. doi:10.1093/ofid/ofaf095
• Yamaguchi H, et al. NT5DC2 downregulation suppresses monoamine oxidase activity and promotes catecholamine synthesis in PC12D cells. Molecular Biology Reports. 2025. doi:10.1007/s11033-025-10900-w
• Yamaguchi H, et al. Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the analysis of NT5DC2-binding proteins. Biochemical and Biophysical Research Communications. 2024. doi:10.1016/j.bbrc.2024.149698
• Okamura K, Dijkstra JM, Tsukamoto K, Yamaguchi H, et al. Discovery of an ancient MHC category with both class I and class II features. PNAS. 2021. doi:10.1073/pnas.2108104118
• Tsukamoto K, Shinzawa N, Kawai A, Yamaguchi H, et al. The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis. Nature Communications. 2020. doi:10.1038/s41467-020-17391-2
• Nakashima A, Yamaguchi H, Kodani Y, et al. Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells. Biochemical and Biophysical Research Communications. 2019. doi:10.1016/j.bbrc.2019.06.156
• Zhong Z, Liu S, Zhu W, Yamaguchi H, et al. Phosphoproteomics reveals the biosynthesis of secondary metabolites in Catharanthus roseus under ultraviolet-B radiation. Journal of Proteome Research. 2019. doi:10.1021/acs.jproteome.9b00267
• Ageta H, Ageta-Ishihara N, Hitachi K, Yamaguchi H, et al. UBL3 modification influences protein sorting to small extracellular vesicles. Nature Communications. 2018. doi:10.1038/s41467-018-06197-y
• Li X, Rehman S, Yamaguchi H, et al. Proteomic analysis of the effect of plant-derived smoke on soybean during recovery from flooding stress. Journal of Proteomics. 2018. doi:10.1016/j.jprot.2018.04.031

受賞

• 2001年 愛知県医師会難病研究奨励賞

researchmap

 https://researchmap.jp/gyaman